Actilis 20 mg (tadalafil) is typically taken once before planned sexual activity. The recommended starting dose is 10 mg, which may be increased to 20 mg or reduced to 5 mg based on effectiveness and tolerance. It should be taken 30–60 minutes prior to intercourse, with effects lasting up to 36 hours. Do not take more than one dose in 24 hours. Always follow your doctor’s advice, especially if you have heart conditions or take nitrate medications.